FRIDLEY — The U.S. Supreme Court won’t hear Medtronic’s appeal of a patent infringement lawsuit.

The high court’s decision could cost the Fridley-based company $250 million in damages.

Medtronic was appealing a ruling that a subsidiary violated a patent on a device that repairs aortic valves without open heart surgery. The patent is held by of Edwards Lifesciences Corp.

Medtronic produces and sells the product outside of the United States. The company could be locked out of the national market.