According to our projections, the best bet in terms of the total among Week 5’s 56 Football Bowl Subdivision games is Wisconsin vs. USC — for more tips, including parlay possibilities, see below.

See computer predictions and insights for that matchup and more in this article.

BetMGM is one of the most trusted Sportsbooks in the nation. Start with as little as $1 and place your bets today.

College Football Computer Picks – Best Spread Bets

Watch college football this season on Fubo and ESPN+.

Pick: Alabama +3.5 vs. Georgia

• Matchup: Georgia Bulldogs at Alabama Crimson Tide
• Projected Winner & Margin: Alabama by 6.1 points
• Time: 7:30 PM ET
• Date: Sept. 28
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Duke +2.5 vs. North Carolina

• Matchup: North Carolina Tar Heels at Duke Blue Devils
• Projected Winner & Margin: Duke by 5.3 points
• Time: 4:00 PM ET
• Date: Sept. 28
• TV Channel: ESPN2
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Oklahoma -2.5 vs. Auburn

• Matchup: Oklahoma Sooners at Auburn Tigers
• Projected Winner & Margin: Oklahoma by 6.8 points
• Time: 3:30 PM ET
• Date: Sept. 28
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Louisville +9.5 vs. Notre Dame

• Matchup: Louisville Cardinals at Notre Dame Fighting Irish
• Projected Winner & Margin: Notre Dame by 5.6 points
• Time: 3:30 PM ET
• Date: Sept. 28
• TV Channel: Peacock

Pick: USC -4.5 vs. Wisconsin

• Matchup: Wisconsin Badgers at USC Trojans
• Projected Winner & Margin: USC by 7.7 points
• Time: 3:30 PM ET
• Date: Sept. 28
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo

Use these spread picks at BetMGM today!

College Football Computer Picks – Best Total Bets

Take advantage of our picks and place your bet at BetMGM today!

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.