Best Bets for NCAA Basketball Picks Against the Spread for Wednesday, February 26

Published 2:22 am Wednesday, February 26, 2025

ATS Pick: Georgetown +12.5 vs. UConn

• Matchup: Georgetown Hoyas at UConn Huskies
• Time: 6:30 p.m. ET
• Date: February 26
• Computer Projection: UConn by 6.3 points (Bet now on BetMGM)
• Spread: UConn (-12.5)
• TV Channel: Fox Sports 1
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

ATS Pick: SMU -2.5 vs. Cal

• Matchup: SMU Mustangs at California Golden Bears
• Time: 11 p.m. ET
• Date: February 26
• Computer Projection: SMU by 6.6 points (Bet now on BetMGM)
• Spread: SMU (-2.5)
• TV Channel: ESPNU
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

ATS Pick: Memphis -13.5 vs. Rice

• Matchup: Rice Owls at Memphis Tigers
• Time: 8 p.m. ET
• Date: February 26
• Computer Projection: Memphis by 16.6 points (Bet now on BetMGM)
• Spread: Memphis (-13.5)
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

ATS Pick: East Tennessee State -9.5 vs. Mercer

• Matchup: Mercer Bears at East Tennessee State Buccaneers
• Time: 6 p.m. ET
• Date: February 26
• Computer Projection: East Tennessee State by 12.6 points (Bet now on BetMGM)
• Spread: East Tennessee State (-9.5)
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

ATS Pick: Holy Cross +9.5 vs. Colgate

• Matchup: Holy Cross Crusaders at Colgate Raiders
• Time: 7 p.m. ET
• Date: February 26
• Computer Projection: Colgate by 6.8 points (Bet now on BetMGM)
• Spread: Colgate (-9.5)
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

Bet on this or any men’s college basketball matchup at BetMGM.

ATS Pick: Lipscomb -19.5 vs. Central Arkansas

• Matchup: Central Arkansas Bears at Lipscomb Bisons
• Time: 8 p.m. ET
• Date: February 26
• Computer Projection: Lipscomb by 22.2 points (Bet now on BetMGM)
• Spread: Lipscomb (-19.5)
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

ATS Pick: Ohio State +1.5 vs. USC

• Matchup: Ohio State Buckeyes at USC Trojans
• Time: 10:30 p.m. ET
• Date: February 26
• Computer Projection: Ohio State by 1.1 points (Bet now on BetMGM)
• Spread: USC (-1.5)
• TV Channel: BTN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

ATS Pick: Utah +14.5 vs. Arizona

• Matchup: Utah Utes at Arizona Wildcats
• Time: 9 p.m. ET
• Date: February 26
• Computer Projection: Arizona by 11.9 points (Bet now on BetMGM)
• Spread: Arizona (-14.5)
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

ATS Pick: American -3.5 vs. Navy

• Matchup: Navy Midshipmen at American Eagles
• Time: 7 p.m. ET
• Date: February 26
• Computer Projection: American by 6 points (Bet now on BetMGM)
• Spread: American (-3.5)
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

ATS Pick: Arizona State +4.5 vs. BYU

• Matchup: BYU Cougars at Arizona State Sun Devils
• Time: 9:30 p.m. ET
• Date: February 26
• Computer Projection: BYU by 2.1 points (Bet now on BetMGM)
• Spread: BYU (-4.5)
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+